Wavelet based features of EEG power spectra analysis in children with borderline intellectual functioning / 中华行为医学与脑科学杂志

Objective@#To investigate the features of absolute electroencephalogram (EEG) power spectra in children with borderline intellectual functioning (BIF) as well as their correlation with cognitive function and behavioral problems.@*Methods@#30 children with borderline intellectual functioning and 42 typical developing children (TDC) were recruited in this study. All of them underwent the Chinese Revised Wechsler Intelligence Scale for Children (C-WISC) and their behavioral problems were assessed according to the Conners’ Parent Symptom Questionnaire (PSQ). Resting EEG of 128 electrodes were recorded when the participants closed their eyes and analyzed using wavelet transform to assess the absolute power of alpha, beta, theta, gamma and theta/beta ratio (TBR).@*Results@#(1)PSQ scores of BIF (conduct problems(0.78±0.16), learning problems(1.53±0.14), psychosomatic disorder(0.17±0.04), impulsivity-hyperactivit(1.13±0.14), anxious(0.52±0.08), hyperactivity inde(1.04±0.10))were higher than TDC(conduct problems(0.21±0.03), learning problems(0.35±0.05), psychosomatic disorder(0.07±0.02), impulsivity-hyperactivit(0.27±0.05), anxious(0.26±0.03), hyperactivity index(0.25±0.04)), and the difference was statistically significant(P<0.05). (2)alpha band: the main effects of the two groups on the left and right hemisphere (F=14.44, P<0.01)and the anterior and posterior hemispheres (F=29.54, P<0.01) were significant.The interaction effect between the left and right hemisphere and the anterior and posteriorm hemispheres was significant(F=8.55, P<0.01). The activity of the alpha wave was significant in the right posterior hemisphere.(3)The main effects of the two groups on the left and right hemispheres (F=6.49, P=0.01)and the anterior and posterior hemispheres(F=8.01, P=0.01) were significant.The two groups had significant interaction effects between the left and right hemisphere and the type(F=5.84, P=0.02). The interaction between the left and right hemisphere and anterior and posterior hemispheres was significant(F=10.51, P<0.01). The activity of the right anterior and right posterior parts was more significant.(4)delta band: the main effects of the two groups were significant in the anterior and posterior hemispheres(F=11.15, P<0.01), and the activities in the anterior hemisphere were larger than those in the posterior hemisphere.(5)TBR: the main effects of the two groups were significant in the anterior and posterior hemispheres(F=4.80, P=0.03). The TBR of the two groups was statistically significant in the right hemisphere(t=2.61, P=0.01).@*Conclusion@#The TBR activity of BIF on the right was higher than TDC.The increased TBR activity in the right hemisphere of BIF may be a neurobiological basis for cognitive impairment such as adaptive behavior disorder and executive function.

Assessment of fetal development by HRV and chaotic global techniques

INTRODUCTION: Fetal heart rate and its variability during the course of gestation have been extensively researched. The overall reduction in heart rate and increase in fetal HRV is associated with fetal growth and the increase in neural integration. The increased complexity of the demands on the cardiovascular system leads to more variation in the temporal course of the heart rate which has been shown to be reflected in measures of complexity. The aim of this work was to investigate novel complexity measures with respect to their ability to quantify changes over gestational age in individual fetuses consistently and in a stable manner. METHODS: We examined 215 fetal magnetocardiograms (FMCG), each of 5 min duration, in 11 fetuses during the second and third trimesters (at least 10 data sets per fetus). From the FMCG we determined the fetal RR beat durations. For each 5 min time-series of RR intervals we then calculated Shannon entropy, high spectral entropy, high spectral Detrended Fluctuation Analysis, spectral Multi-Taper Method as well as the standard deviation and two commonly used complexity measures: Approximate Entropy and Sample Entropy. For each subject and HRV measure, we performed regression analysis with respect to gestational age. The coefficient of determination R² was used to estimate 'goodness-of-fit', the slope of the regression indicated the strength of the individual dependency on gestational age. RESULTS: We found that the new complexity measures do not outperform ApEn. CONCLUSION: This study has now rejected the hypothesis that the spectral complexity measures outperform those applied previously.

INTRODUÇÃO: A freqüência cardíaca fetal e da sua variabilidade durante o curso da gestação têm sido extensivamente pesquisada. A redução global da frequência cardíaca e aumento da VFC fetal está associada com o crescimento fetal e aumento da integração neural. O aumento da complexidade das exigências sobre o sistema cardiovascular conduz a uma maior variação no decurso temporal da frequência cardíaca o que foi mostrado para reflectir-se medidas de complexidade. O objetivo deste trabalho foi investigar medidas de complexidade novos em relação à sua capacidade de quantificar as mudanças ao longo da idade gestacional em fetos individuais de forma consistente e de forma estável. MÉTODO: Foram examinados 215 magnetocardiograms fetais (FMCG), cada um dos 5 min de duração, em 11 fetos durante o segundo e terceiro trimestres (pelo menos 10 conjuntos de dados por feto). A partir do grande consumo determinamos as durações RR batimento fetais. Para cada série temporal 5 min dos intervalos RR então calculada Shannon entropia, alta entropia espectral, alta espectral Destendenciada Análise Flutuação, espectral Multi-Taper Método, bem como o desvio padrão e duas medidas de complexidade comumente utilizados: aproximado Entropia e Amostra Entropia. Para cada medida assunto e HRV, foi realizada análise de regressão em relação à idade gestacional. O coeficiente de determinação R² foi usada para estimar a "o bem-of-fit", a inclinação da regressão indicou a força do indivíduo dependência da idade gestacional. RESULTADOS: Verificou-se que as novas medidas de complexidade não superar ApEn. CONCLUSÃO: Este estudo agora rejeitou a hipótese de que as medidas de complexidade espectrais superar os aplicados anteriormente.

The modulatory effect of transcutaneous electrical nerve stimulation (TENS) on tonic heat pain in the human brain: topographic mapping of absolute EEG power spectra / 中华行为医学与脑科学杂志

Objective To investigate the effect of transcutaneous electrical nerve stimulation (TENS) on baseline eyes-closed brain activation and on pain-related EEG activity when TENS is applied contralatarally to the hand of pain. Method 128-channel electroencephalography (EEG) was recorded in four conditions including baseline,heat pain test,TENS stimulation and contralateral TENS modulation in 15 right-handed healthy young males. The Short Form McGill Pain Questionnaire was employed to assess pain sensation. Fast Fourier Transformation analysis (FFT) was performed to calculate absolute EEG power spectra based on 7 bands spectrum. Results ① The fronto-central beta-1 activity was significantly enhanced by TENS compared to eyes-closed [eyes-closed:(290±201)μV2,TENS:(385±224)μV2,t=3.323,P<0.01].②TENS markedly relived pain sensation assessed by SF-MPQ and significantly increased the posterior-anterior alpha-1 power [pain:(332±221)μV2,TENS modulation:(378±243)μV2,t=3.683,P<0.01] and fronto-central and posterior beta-1 activities [pain:(348±213)μV2,TENS modulation:(397±240)μV2,t=2.362,P<0.05]. Conclusion TENS,used as a peripheral nerve stimulation,mainly activates sensorimotor cortex.The increased Alpha-1 activity implies that TENS is likely able to relieve pain affective.

Effects of ciprofloxacin on the heart and brain electrical power spectra of rats / 重庆医科大学学报

Objective:To evaluate the effects of ciprofloxacin on the heart and brain electrical power spectra of rats.Methods:Male wistar rats received ciprofloxacin 100mg/kg through their jugular vein.The heart and brain electrical power spectra of rats were recorded before administration as contrast,and at 10,20,30,60,120 minutes after administration as experiments respectively.RR 512 soft ware was used to analyze heart electrical RR variance and low frequency power and high frequency power,and Coherence software was employed to study brain electrical ?,?,?,? power.Results:At 10 - 6 0minafter do sage ,heartelectrical RRvariance was distinct lylarger,and low frequencypower was evidentlylower,and highfrequencypower was signi ficantly higher than those determined be foreadministration .SpikewavesfrequentlyappearedintheECOGofratsat 13minto 6 0minafteradministration .At 10minafter dosage,thebrainelectricaltotalpowerand?powerweredistinctlylowerthanthosebeforeadministration .At 12 0min ,?,? ,?wave powerwereobviouslyhigher,and?/?and?/(? +? +?)valuewereevidentlylowerthanthosebeforeadministration ,buttheywere notchangedatothertimes.Conclusion :The excitability of sympathe ticnerv eof the heartwas weakened and the irritability of pneu mogastricnerve was enhanced ,and the hear tratevariabi lity in creases,and the excitability of centralnerve was induced by cipr of loxacin .